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Symbol Name ID |
Egr2
early growth response 2 MGI:95296 |
| Darker colors indicate more annotations |
| Human Phenotypes | Tongue fasciculations |
Increased CSF protein concentration |
Decreased number of peripheral myelinated nerve fibers |
Onion bulb formation |
Peripheral demyelination |
Segmental peripheral demyelination/remyelination |
Myelin tomacula |
Peripheral hypomyelination |
Abnormal cranial nerve morphology |
Hypertrophic nerve changes |
Decreased motor nerve conduction velocity |
Decreased sensory nerve conduction velocity |
Areflexia |
Hyporeflexia |
Broad-based gait |
Steppage gait |
Motor delay |
Peripheral neuropathy |
Distal sensory impairment |
Impaired distal vibration sensation |
Sensory ataxia |
| Disease(s) Associated with EGR2 | |||||||||||||||||||||
| Charcot-Marie-Tooth disease type 1D | |||||||||||||||||||||
| Charcot-Marie-Tooth disease type 3 | |||||||||||||||||||||
| Charcot-Marie-Tooth disease type 4E |
| Mouse Phenotypes | increased Schwann cell proliferation |
abnormal neural tube morphology |
abnormal rhombomere morphology |
absent rhombomere 3 |
decreased rhombomere 3 size |
absent rhombomere 5 |
decreased rhombomere 5 size |
decreased rhombomere 6 size |
abnormal hindbrain development |
abnormal Schwann cell morphology |
abnormal neuromuscular synapse morphology |
abnormal somatic nervous system morphology |
abnormal cranial ganglia morphology |
abnormal cochlear ganglion morphology |
abnormal geniculate ganglion morphology |
abnormal glossopharyngeal ganglion morphology |
abnormal trigeminal ganglion morphology |
abnormal vagus ganglion morphology |
abnormal cranial nerve morphology |
abnormal abducens nerve morphology |
abnormal facial nerve morphology |
abnormal glossopharyngeal nerve morphology |
fusion of glossopharyngeal and vagus nerve |
abnormal trigeminal nerve morphology |
abnormal vagus nerve morphology |
abnormal sciatic nerve morphology |
abnormal myelination |
decreased nerve conduction velocity |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||
| Egr2tm1Grid/Egr2tm1Grid | |||||||||||||||||||||||||||||
| Egr2tm1Jmi/Egr2tm1Jmi | |||||||||||||||||||||||||||||
| Egr2tm1Pch/Egr2tm1Pch | |||||||||||||||||||||||||||||
| Egr2tm2Jmi/Egr2tm2Jmi | |||||||||||||||||||||||||||||
| Egr2tm4Pch/Egr2tm4Pch | |||||||||||||||||||||||||||||
| Egr2tm1Pch/Egr2tm3Pch | |||||||||||||||||||||||||||||
| Egr2tm2Jmi/Egr2+ | |||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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